It may be that a person will commit such a great sin, or so many sins, without repenting, that God will then respond by not granting him an opportunity to repent from the bad ways that he has freely chosen to follow. Then when the sinner eventually dies, his soul will be “cut off” because of the seriousness of the unrepentant sins that he committed against God. This is implied in the words of the Holy One, blessed be He, which were related by Isaiah: “Fatten the heart of this people, harden its ears, and seal its eyes, lest it see with it eyes, hear with its ears and understand with its heart, so that it will repent and be healed.” Similarly, it is stated, “But they mocked the messengers of God, scorned His words, and scoffed at His prophets, until the anger of the Lord mounted up against His people until there was no remedy.” This verse means that the people willingly sinned and multiplied their iniquity until it was determined by God to hold back their repentance, which is referred to as the “remedy”. (Seven Gates of Righteous Knowledge by Rabbi Moshe Weiner and Dr. Michael Schulman, Ask Noah International, 2017, p 169)