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He said McCain "refuses to understand or acknowledge the failure of the policy that he would continue. He criticizes my willingness to use strong diplomacy, but offers only an alternate reality — one where the war in Iraq has somehow put Iran on its heels. The truth is the opposite."
Obama was followed on stage by Sen. Hillary Rodham Clinton, whom he had warmly praised. She did not formally concede the nomination to him but told the audience that Obama "will be a good friend to Israel."
Some Jewish voters are wary of Obama partly because his former pastor praised Black Muslim leader Louis Farrakhan, who has made anti-Semitic remarks. Obama has disavowed the pastor's intemperate remarks and later resigned from that church.
Obama also cited e-mails "filled with tall tales and dire warnings about a certain candidate for president," a reference to false accusations that he is a Muslim with a hidden agenda. "Let me know if you see this guy named Barack Obama, because he sounds pretty scary," he said.
Obama clearly impressed some in the massive hall.
"He had me in tears, this feeling for an understanding of Israel's predicament," said Leonard Eisenfeld, a Connecticut pediatrician whose son was killed in a Hamas bus bombing in Jerusalem in 1996. He said he respects McCain, but is now more open to Obama, calling him a "good soul" in Yiddish.