The Bible warns that the thinking of those who reject God will eventually become futile, "Although they claimed to be wise, they became fools". Romans 1:22. the Bible says we are to resist evil instincts and sinful desires that war against your soul. Fight the good fight of faith. "The one who sows to please his sinful nature will reap destruction, the one who sows to please the Spirit, from the Spirit, will reap eternal life." Galations 6:8. the Bible also says a man is not to wear a woman's clothing. Deuteronomy 22:5.
People 3000 years ago struggled with the same inner feelings and confusions, suggesting that transgender desires are not newly invented impulses, but they are definitely contrary to God's will, just like homosexuality. Sex change is biologically impossible. The changes are either more feminine or masculine, but do not change from men to women or vice versa. The DNA remains the same. In reality mutilating the body is a mental disorder.