Yes, I have had many American cars that ran well over 200,000 miles and never replaced an engine or transmission on any of them... I had a 1962 Dodge that ran well over 200 thousand miles when I sold it 1991. I sold it to a guy for a few hundred bucks that needed a reliable car for local transportation to the hospital where he was undergoing some sort of treatments...The car had been in my family since 1968 and I was glad that the car was going to someone that needed it...I would see the car on the road from time to time after I sold it and it was funny to see an old car like that being used as the family car. I met his son in a store years later and he said his family went everywhere with that old car. He was around 10 or 12 when his father bought the car and the car lasted so many more years that kid actually learned to drive on the car. He said it was also his first car.
I also had a 1979 Chrysler that had well over 250,000 miles on it that also never had any major work done to it... I had an accident back in 1995 with a lady that passed a stop sign. The accident damaged the car in a bad spot and seeing that the car was so old it was not worth the work to repair it... I am sure the car would have gone on for a few more years had it not been involved in the accident..
The 1998 Ford car I have now just went past the 300,000 mark. I use the car every day and it still looks like its only a year or two old... I am working on getting passed 400,000 with it.